ACE has an activity of beta-amyloid amyloid-degrading enzymes (ADEs) that can hydrolyze and convert Aβ1-42 to Aβ1-40 in homogenates of the mouse Tg2576 AD model and human AD autopsy [47], which is consistent with its dipeptidyl carboxypeptidase activity that cleaves the c-terminal two amino acid residues. This evidence concerns the gene ACE and Alzheimer disease.