VEGFA and obesity due to melanocortin 4 receptor deficiency: Gomes et al. [82] showed that obesity could lead to decreased expression of miR-126 and an increased PI3KR2, which inhibits a key regulator of the VEGF signalling pathway PI3K, thus causing capillary rarefaction in skeletal muscle in the obese rat model, whereas aerobic exercise training, such as swimming, can reverse this negative impact by normalizing miR-126 level and restoring VEGF signalling.