NPPB and cancer: Albeit the promising prospect of miRNAs as potential biomarkers for exercise-based cancer rehabilitation, there are several issues remaining to be resolved: (1) clinical correlation between miRNAs expression in specific tissues and their expression in blood as well as physiological and physical parameters in cancer rehabilitation should be established due to the lack of related investigation; (2) the changing pattern of miRNAs differs from conventional biomarkers after exercise: NT-proBNP and hs-CRP increased after the marathon and stay elevated after 24h of race completion.