IGF1 and metabolic syndrome: A randomized controlled trial from overweight or obese breast cancer survivors showed that, when compared with usual care, participants who received 16 weeks of combined aerobic and resistance exercise intervention had physiologically improved metabolic syndrome z-score, sarcopenic obesity, and circulating biomarkers, such as insulin, insulin-like growth factor-1 (IGF-1), leptin, and adiponectin [10].