In the same way, for canine mammary tumor cell line CF41, E-CADHERIN gene expression increased after treatment with carboplatin, losartan, or both in combination (p < 0.05; Figure 4A), while N-CADHERIN and PARP-1 gene decreased significantly after treatment with carboplatin, losartan, or carboplatin in combination with losartan compared to the control group (p < 0.05; Figure 4B,C). The gene discussed is PARP1; the disease is breast cancer.