PARP1 and breast cancer: Likewise, for canine mammary tumor cell line CF41.Mg, there was a statistically significant increase in E-cadherin (p < 0.0001; Figure 2A) protein expression and decrease in N-cadherin (p < 0.0001; Figure 2B), and PARP-1 (p < 0.0001; Figure 2C) after treatment with carboplatin, losartan, and with both in combination compared to the control group (without treatment).