In colorectal and breast tumor cells, nitrosylation of cIAP1, a member of the Inhibitor of Apoptosis (IAP) family of proteins [133], has been found to impair its TNF-α-dependent E3 ubiquitin ligase activity and degradation of receptor-interacting serine/threonine protein kinase 1 (RIP1). The gene discussed is RIPK1; the disease is breast neoplasm.