In this study, we characterized the plasma 1H-NMR glycoprotein profile of T2DM patients with and without AD; we explored its association with their advanced NMR lipoprotein profile; and, finally, we compared the ability of these new NMR based on inflammatory markers to discriminate specific patterns between study groups, other than those commonly used in clinical settings, including traditional risk factors and CRP. This evidence concerns the gene CRP and type 2 diabetes mellitus.