A known variant of POT1, with D224N mutation, disrupts POT1 binding to ssDNA telomere oligonucleotides, leading to longer and fragile telomeres, predisposing for chronic leukocyte leukemia, glioma, angiosarcoma, osteosarcoma, thyroid cancer, colorectal cancer, and cutaneous melanoma [110]. This evidence concerns the gene POT1 and cutaneous melanoma.