Vx-001 is a peptide-based cancer vaccine consisting of two peptides: hTERT-derived low-affinity cryptic hTERT peptide: TERT 572 (RLFFYRKSV; ARG-Vx001) and its optimized mutant hTERT peptide: TERT 572Y (YLFFYRKSV; TYR-Vx001), which has an enhanced affinity to MHC class I molecules as the first amino acid was replaced with a tyrosine residue [285]. The gene discussed is TERT; the disease is cancer.