The G-rich oligos, which homolog to the telomeric overhang that forms the G4 structures, cause telomere dysregulation and a decreased proliferation rate, enhance apoptosis, and reduce expression of the TERT within melanoma cells [321].An alternative approach is based on telomere uncapping, using nucleoside analogs(e.g., 6-thio-dG) that rapidly affect telomere dysfunction, quickly triggering cancer cell death [322]. Here, TERT is linked to melanoma.