STAT3 and glioblastoma: In this regard, STAT3 tyrosine 705 phosphorylation (STAT3 (Tyr705)) mediates the invasion of GBM cells by upregulating uPA, MMP-2 and MMP-9 [26,27], the decreased levels of STAT3 (Tyr705), uPA and MMP-9 by magnolol strongly indicate a counteraction from magnolol to GBM cell invasion.