In correspondence to other previous findings that the decreased expression of STAT3 (Tyr705) was correlated with favorable survival in patients with GBM [28] while STAT3 silencing by siRNA reduced the invasion of GBM cells [29], the invasion of GBM8401 cells in this study was shown to be significantly suppressed by treatment with either magnolol or STAT3 inhibitor (Figure 3). Here, STAT3 is linked to glioblastoma.