We analysed SDHB and PKM2 concentrations in the PBMC fraction to further investigate the clinical significance of SDHB and PKM2 relative gene expression in the peripheral blood of patients with RA; we observed that at baseline, SDHB and PKM2 protein expressions in PBMCs were significantly lower in patients with RA who achieved remission than in other patients with RA (Figure 1C,D). Here, SDHB is linked to rheumatoid arthritis.