Here, in our preliminary study, we hypothesised that the expression of genes involved in energy-generating metabolic pathways: glycolysis (PKM2) and oxidative phosphorylation (succinate dehydrogenase subunit B (SDHB)) measured in the peripheral blood of TOFA-naive patients with RA prior to TOFA therapy may serve as useful biomarkers to identify patients who may show remission. Here, PKM is linked to rheumatoid arthritis.