TYMS and colorectal carcinoma: To determine if TYMS upregulation of visfatin induction influences the cytotoxicity of capecitabine in human DLD-1 CRC cells, cells were pretreated with vehicle (PBS) or visfatin (50 ng/mL) for 1 h and then kept as control or treated with capecitabine (2.5, 5, and 10 μM) for 24 h.