EGFR and hepatocellular carcinoma: In particular, in HCC, to understand how it works, lnc-EGFR specifically interacts with EGFR and prevents it from interacting with and being ubiquitinated by the cell death protein (c-CBL), thereby stabilizing it and increasing the activation of itself and the downstream activator protein-1 (AP-1)/nuclear factor of activated T cell-1 (NF-AT1) axis, which in turn induces EGFR expression [57].