highly expressed in MM and is associated with the survival rate of MM patientsPDIA3P regulates MM growth and drug resistance through glucose 6-phosphate dehydrogenase (G6PD) and the pentose phosphate pathway (PPP)PDIA3P interacts with c-Myc to enhance its transactivation activity and binding to G6PD promoter, stimulating G6PD expression and PPP fluxPDIA3P is overexpressed in U266 cells in the presence of bortezomib and overexpression of PDIA3P restored the inhibitory effect of bortezomib on cell proliferation. Here, MYC is linked to Miyoshi myopathy.