DUXAP10 was certified to be upregulated in ESCC tissues and cellspositively correlated with short survival timedown-expression of DUXAP10 contributed to decreased cell proliferation and metastasisknockdown of DUXAP10 caused the increased apoptosis rate and stopping of cell cycleDUXAP10 through recruiting enhancer of zeste homolog 2 (EZH2) to the promoter of p21 influenced on ESCC progression. The gene discussed is EZH2; the disease is esophageal squamous cell carcinoma.