it is upregulated in patient tissues and cell linesknockdown of DUXAP8 represses proliferation, migration, invasion, EMT process and phosphorylation of AKT/mTORDUXAP8 has positive correlation with TRIM44, while the miR-498 and DUXAP8, as well as miR-498 and TRIM44, are negatively correlatedDUXAP8 regulates the expression of TRIM44 by miR-498knockdown of DUXAP8 decreases the tumor volume and weight as well as the number of metastatic nodules in vivo. This evidence concerns the gene AKT1 and neoplasm.