BMI1P1A and OCT4 and POU5F1B make up a three-gene signature that divides patients into high-risk and low-risk groupsthe three-gene signature is a more valuable signature for distinguishing between patients and controls than any of the three genesthe three-gene signature was a prognostic factor: high-risk patient group has shorter leukemia-free survival (LFS) OS than the low-risk group. Here, POU5F1B is linked to leukemia.