it is downregulated in patient samples and cell linesoverexpression of AOC4P reduces viability, invasion, the expression of MMP-2 and MMP-9, apoptosis and caspase-3/7 activityAOC4P overexpression suppresses tumor growth in vivothe activation of the Wnt/β-catenin pathway by BML-284 reduces the effects of AOC4P overexpression. The gene discussed is MMP9; the disease is neoplasm.