it is upregulated in patient samplesit is positively correlated with tumor size, TNM stage, and poor survivaloverexpression of PTTG3P promotes cell proliferation, migration, and invasion in vitro, as well as tumorigenesis and metastasis in vivoover-expression of PTTG3P upregulates PTTG1 and activates PI3K/AKT signaling and influences cell cycle progression, cell apoptosis and EMT. The gene discussed is AKT1; the disease is neoplasm.