PFKFB3 and neoplasm: highly expressed in many cancershigh expression levels are correlated with poor prognosisit is a transcriptional target of TP53 and loss or mutation of TP53 induces upregulation of AGPGAGPG protects PFKFB3 from proteasomal degradation and leads to the accumulation of PFKFB3, which in turn activates glycolytic flux and promotes cell cycle progressionknockdown of AGPG results in tumor growth in patient-derived xenograft models