it is upregulated in patient samples and cell linespositively correlated with AKR1B10AKR1B10P1 is connected with larger tumor size, more advanced TNM stages, higher serum Alpha-fetoprotein (AFP) quantity, tumor microsatellite formation, and liver cirrhosisknockdown of AKR1B10P1 reduces cell proliferation, induces cell cycle arrest and cell apoptosis, and impairs the ability of cell mobilityAKR1B10P1 influences EMT by directly interacting with miR-138 which regulates SOX4, a pivotal promotor of EMT. This evidence concerns the gene SOX4 and digestive system neoplasm.