it is downregulated patient tissues and cell lineslower expression is correlated with larger tumor size, advanced TNM stage, Lauren’s classification, positive lymph node metastasis; lower expression is connected with poor prognosisupregulation of KRT19P3 inhibits cell proliferation, migration, and invasion in vitro, as well as tumorigenesis and metastasis in vivoKRT19P3 directly binds to COPS7A, regulates it expression, and suppress tumor growth and metastasis through COPS7A-mediated NF-κB pathway. The gene discussed is KRT19P3; the disease is neoplasm.