SUMO1P3 expression was elevated in pancreatic tissues compared with the corresponding adjacent normal tissuesthe data indicated that the increased expression of SUMO1P3 is significantly associated with tumor progression and the poor survival of patients with pancreatic cancerSUMO1P3 knockdown may suppress the proliferation, migration, and invasion of pancreatic cancer cellsdownregulation of SUMO1P3 suppressed the EMT and increased the expression of epithelial cadherin, and decreased the expression of neuronal cadherin, vimentin, and β-catenin. This evidence concerns the gene CDH1 and familial pancreatic carcinoma.