it is upregulated in the gefitinib-resistant cellshigher expression is closely correlated with worse patient prognosisit promotes the proliferation and invasion and knockdown of FTH1P3, represses the tumor growth in vivotranscription factor E2F1 accelerates the transcription of FTH1P3FTH1P3 recruits LSD1 and epigenetically represses the TIMP3, which leads to the tumorigenesis. The gene discussed is TIMP3; the disease is neoplasm.