it is downregulated in patient samples and cell lines, especially in advanced and more aggressive forms of cancerhigher level is connected with poor clinical prognosisPTENP1 regulates cell proliferation, invasion, tumorigenesis, and chemoresistance to Adriamycin (ADR)PTENP1 is a direct target of miR-20a and regulates miR expression in sponging-dependent manner and in turn influences PTEN expressionPTENP1 activates the PI3K/AKT pathway and PI3K inhibitor LY294002 or siAKT prevents cancer progression. The gene discussed is PTENP1; the disease is cancer.