Further mutations, such as SF3B1, KRAS, NRAS, BRAF, MYD88, EGR2, MAP2K1, ATM, NOTCH1, POT1, CHD2, XPO1, BIRC3, MED12, FBXW7, ASXL1, NFKBIE, TRAF3, RPS15, and DDX3X are also seen in CLL patients. The gene discussed is ASXL1; the disease is B-cell chronic lymphocytic leukemia.