ASXL1 and myeloid neoplasm: Of note, ASXL1 mutations are frequently seen with other gene alterations, such as with EZH2 IDH1/2, RUNX1, and TET2 [194,256], most of which are adverse prognostic factors themselves in myeloid neoplasms, potentially explaining why ASXL1 mutations are associated with poor prognosis in many cases [257].