According to the current World Health Organization (WHO) Classification of Tumors of Hematopoietic and Lymphoid Tissues, numerous genetic changes are highlighted, defining a distinct subtype of diseases (AML with recurrent genetic abnormalities), such as the ones involving RUNX1, CBFB-MYH11, PML-RARA, BCR-ABL1 etc. Also, there is a separate category for myeloid neoplasms with germline mutations, including DDX41 and CEBPA, amongst others. The gene discussed is RUNX1; the disease is acute myeloid leukemia.