LEP and obesity due to melanocortin 4 receptor deficiency: The correlation analysis (Figure 1) showed a significant positive correlation between the markers of obesity and diabesity—adiponectin: adipsin; adipsin: ANGPTL4; c-peptide: insulin, leptin, PAI-1, leptin/adiponectin ratio, ANGPTL3; ghrelin: resistin; GIP: GLP-1, insulin, visfatin; GLP-1: PAI-1; glucagon: resistin, visfatin; insulin: leptin, PAI-1, leptin/adiponectin ratio, ANGPTL3; leptin: PAI-1, leptin/adiponectin ratio, ANGPTL3; PAI-1: leptin/adiponectin ratio; resistin: visfatin; leptin/adiponectin ratio: ANGPTL3; and ANGPTL3: ANGPTL4.