Autoimmunity type I (IgE autoantibodies to IL-24, thyroperoxidase, double-stranded DNA, and other autoallergens) or type IIb (IgG antibodies to the patient’s own IgE or its high-affinity receptor-FcεRI) are involved in a large proportion of CSU cases [8], but also other factors have been elucidated: infections, pseudoallergic reactions, coagulation, stress, vitamin D [9]. The gene discussed is IGHE; the disease is infection.