AKT1 and neoplasm: Protein kinase-B or AKT action is correlated with drug resistance, especially for antineoplastic agents such as cisplatin, 5-fluorouracil (5-FU), mitomycin C, and doxorubicin [60], via its stimulatory effect on mTOR, leading to the inactivation of autophagy and the accumulation of defective molecules, as well as tumor cell growth and multiplication [33].