However, these Keap1/Nrf2 pathways are complex processes, and emerging experimental data have recently been published regarding the conflicting roles of Nrf2 in adipogenesis, insulin resistance, obesity, insulin sensitivity, and inflammation—partly because of the diversity of Nrf2-mediated functions [26,156,157]. This evidence concerns the gene NFE2L2 and obesity due to melanocortin 4 receptor deficiency.