Recently, Cabrita et al. [51] found that the coexistence of tumor-associated CD8+ T cells and CD20+ B cells improved survival in patients with metastatic melanomas; immunofluorescence staining of CXCR5 and CXCL13 in combination with CD20 showed the formation of TLSs in these CD8+ CD20+ tumors. This evidence concerns the gene CD8A and neoplasm.