The interaction between LTαβ and LTβR on PC cells triggers the IKKa-E2F1-BMI1 pathway, which regulates the regeneration of oncogenic prostate stem cells [177,178] and phosphorylates STAT3, an anti-apoptosis and oncogenic transcription factor [179], as a result of the reconstruction of PC cells, accelerating the emergence of CRPC [87,115]. This evidence concerns the gene E2F1 and pachyonychia congenita.