The CXCL13/CXCR5 axis is involved in the regulation of cancer cell survival, apoptosis, proliferation, differentiation, migration, invasion, and adaptive immunity, and shows dichotomic anti- and pro-tumor functions in the TME [21,50,73,74,75,76,77,78] (Figure 4). The gene discussed is CXCR5; the disease is neoplasm.