Moreover, in the NOD/SCID mice bearing A549-Luc-CXCL13 cells, CXCL13 recruits CXCR5+ CD68+ macrophages to the TME, where macrophages produce secreted phosphoprotein 1 (SPP1) to promote cell migration and tumor progression. This evidence concerns the gene CXCL13 and neoplasm.