A few reports regarding breast and lung cancers have shown that the CXC13/CXCR5 axis attracts B cells and Tfh [89,90] to shape the TLS in the peritumoral or tumor sites (Figure 7B), which is associated with adaptive anti-tumor humoral responses and predicting responses to PD-1 blockade therapy. This evidence concerns the gene CXCR5 and lung cancer.