In prostate cancer, CXCL13/CXCR5 interactions promote the progression of tumor cells, including proliferation and metastasis, which are triggered by multiple signaling cascades, such as ERK, PI3K/Akt, stress-activated protein kinase (SAPK)/c-Jun kinase (JNK), Rac, and protein kinase C epsilon (PKCε)/nuclear factor kappa B (NF-κB) [100,101,122,123]. This evidence concerns the gene MAPK8 and Familial prostate cancer.