On one hand, CXCL13 attracts immunosuppressive cells to mediate immune suppression or evasion, leading to tumor progression, while on the other hand, the CXCL13/CXCR5 axis elicits tumoricidal immunity signaling to escape tumor immunosurveillance in some cancer types [54,89,141] (Table 1). This evidence concerns the gene CXCR5 and cancer.