The malignant B cells from CLL or acute lymphocytic leukemia (ALL) patients take advantage of the CXCR5/CXCL13 axis and the CCR7/CCL19 axis for resistance to TNFα-induced apoptosis via upregulation of paternally expressed gene 10 (PEG10) and subsequent stabilization of caspase-3 and caspase-8 [105]. This evidence concerns the gene CASP8 and acute lymphoblastic leukemia.