CXCL13, as well as other homeostatic chemokines, including CXCL12, CCL21, and CCL19, make crucial contributions to B-CLL cell survival through phosphorylating MAPK extracellular signal-regulated kinase (ERK)1/2, p90RSK, and protein kinase B (Akt), and inhibiting phosphorylation of the downstream effectors GSK3α/β and FOXO3a [103]. Here, CXCL13 is linked to B-cell chronic lymphocytic leukemia.