In colorectal or colon cancer, the CXCL13/CXCR5 axis mediates the pathogenesis, development, and distal metastasis of tumor cells through upregulating the expression and secretion of MMP13, as well as activating the PI3K/Akt pathway [98,125,187,188]. This evidence concerns the gene CXCR5 and malignant colon neoplasm.