A genetic association study in the Chinese Han population of 464 breast cancer cases and 467 healthy controls did not observe any significant association with breast cancer risk for two SNPs, rs3741219 and rs217727, in the H19 gene in the overall analysis, but on stratified analysis, rs217727 SNP was found to correlate with breast cancer risk in patients with ER+ or HER2+ or women who had more than two pregnancies [89]. Here, ESR1 is linked to breast carcinoma.