While knockdown of H19 in PC3 and DU145 prostate cancer cells reduced cell proliferation and glucose and lactate levels [46], the H19-derived miR-675 axis is described as a suppressor of prostate cancer metastasis, regulating extracellular matrix protein and transforming growth factor β-induced protein (TGFB1) [47]. This evidence concerns the gene TGFB1 and Familial prostate cancer.