ELFN1 and CCDC112: Using trio analysis we identified two de novo missense variants in the ELFN1 and CCDC112 genes in patient T62 with SM (−3.6), delayed myelination, asymmetric cerebral hemispheres, epileptic encephalopathy, hypotonia, sensorineural hearing loss, myopia and astigmatism. Here, CCDC112 is linked to Epileptic encephalopathy.