The first module of three TGFβ-mediated SMAD signaling pathways is regulated by the largest number of selected miRNAs, associated with cardiac hypertrophy: hsa-miR-19b-3p, hsa-miR-21-5p, hsa-miR-29a-3p, hsa-miR-93-5p, hsa-miR-155-5p, hsa-miR-221-3p, hsa-miR-222-3p, and hsa-miR-451a. The gene discussed is TGFB1; the disease is cardiac hypertrophy.