HMGN1 and Dravet syndrome: Our results showed that methyl CpG-binding protein 2 (MeCP2) is underexpressed in several structures of the brain of DS, which can be linked to the dysregulation of the HMGN1 gene, given that this latter gene can affect the expression of MeCP2 by changing the chromatin structure and histone modifications in the MeCP2 promoter [40].