DHCR7-DT and age-related macular degeneration: In contrast, the AP gene variants conferring risk for AMD and DDD were not risk variants for another renal disease associated with complement dysregulation, atypical haemolytic uremic syndrome (aHUS), a disease characterised by thrombocytopenia, microangiopathic haemolytic anaemia, and acute renal failure with complement deposition in the kidney [14].