In another study, it is reported that there are about 14 essential genes involved in oral cancer genesis from leukoplakia, including Signal Transducer and Activator of Transcription 5B (STAT5B) and Epidermal Growth Factor Receptor (EGFR), and eight miRs, such as miR-549, miR-205, and miR-21 [71]. This evidence concerns the gene STAT5B and Oral leukoplakia.