Although non-HFE related HH due to mutations on the HFE2 gene is classically known as juvenile hemochromatosis, cases of non-HFE related HH with mutations in TFR2 gene are also young patients (A.II.1 35 years old, A.II.2 37 years old, B.II.1 46 years old and C.II.2 25 years old). The gene discussed is TFR2; the disease is hemochromatosis type 2.