TP53 and obstructive sleep apnea syndrome: Rare familial sporadic forms of OSA have been reported to be caused by pathogenic variants in genes such as CHEK2, RB1, and TP53 (OMIM 259500) with an essential function in cell survival pathways that play a role in genome stability (RB1, TP53, CDK4, MDM2, ATRX) [2].