For example, BIN1 has been found to interact with coding products of similar functional pathways affected in AD, such as PICALM, MAPT, ABCA7 or SORL1; CLU and ApoE have additive effects on lipid trafficking and affect Aβ deposition and ABCA7 interacts with the major risk candidate genes BIN1, CLU and PICALM [30] (the epistatic interactions between these and other coding protein genes are shown in Figure 1). The gene discussed is CLU; the disease is Alzheimer disease.