For example, one of the largest GWAS-based meta-analyses published to date on AD showed no genome-wide significance for the myeloid cell surface antigen (CD33) and Desmoglein 2 (DSG2) genes [85], whereas CD33 was later found to have a strong association with an increased AD risk in Caucasian and Asian populations [86,87]. Here, CD33 is linked to Alzheimer disease.