APOE and Alzheimer disease: Last year, for example, Meng et al. found known risk factors such as the ApoE and APOC1 genes after applying multivariate screening based on the extended Simes method (GATES), together with a PPI network analysis, to eight subcortical measures of the AD neuroimaging phenotype, and also discovered novel genetic variants (LAMA1, XYLB or NPEPL1) with potential influence on the disease [98].