Other potentially involved genes (GATA Binding Protein 4, GATA4; T-Box Transcription Factor 20, TBX20; NK2 Homeobox 5, NKX2-5; Zic Family Member 3, ZIC3) were initially recognized as pathogenic for Atrial Septal Defects (ASD) [12,13]. This evidence concerns the gene NKX2-5 and Abnormal cardiac septum morphology.