For example, the top five (by p-value) differentially expressed genes (DEGs) in the list are all linked to cardiovascular atypicalness: T Cell Receptor Alpha Constant (TRAC) was assigned by Human Phenotype Ontology (HPO) as a gene involved in abnormality of the cardiovascular system, while the Human Protein Atlas (HPA) defines F13A1, PROS1 and CP as “candidate cardiovascular disease genes”; Cysteine Rich Secretory Protein LCCL Domain Containing 2 (CRISPLD2) was described as gene involved in the promotion of cardiac ischemia/reperfusion injury [19]. The gene discussed is PROS1; the disease is myocardial ischemia.