Notable, for the first time, we observed and validated that NEAT1 was under-expressed in DCM patient tissues and there was a significant association between the expression levels of NEAT1 and LVEDD (Rho = 0.73, p = 0.05) according to severe functional status (NYHA-classIII) (Table S7). This evidence concerns the gene NEAT1 and familial dilated cardiomyopathy.