In colorectal cancer-initiating cells (CCICs), ANKRD22 cooperates with the lipid transport protein extended synaptotagmin-1 (ESYT1) to transport excess lipids into the mitochondria and reduce the number of mitochondria in an autophagy-independent manner, thus meeting the metabolic requirements of CCICs [51]. The gene discussed is ESYT1; the disease is colorectal cancer.