Variants found in GJB2 (c.231G>A), and SLC26A4 (c.1337A>G) have been previously reported in families with HL [10,11,12], and have categorized as “pathogenic” or “likely-pathogenic” according to ACMG/AMP guidelines [13], while the other three variants are novel and based on the available evidences fall into the “uncertain significance” category [13,14] (Table 2). The gene discussed is GJB2; the disease is Hodgkins lymphoma.