This study presents a HL family GCUFAHL38, in which five different deafness genes (GJB2, SLC26A4, CDH23, MPDZ, KCNQ4) rare variants were co-segregating in different configurations (Figure 1A), and thus further highlights the genetic complexity of hearing disorders in highly inbred families. The gene discussed is KCNQ4; the disease is hearing disorder.