Our in silico analysis revealed that a total of 12 genes (ABCA1, ADRBK2, ANKRD52, DEPDC1B, FXR1, ITGA3, KLF12, NLK, PCDH17, PDE7A, PXN, and SLC24A2) are regulated by miR-199-5p and miR-199-3p in HNSCC cells. The gene discussed is GRK3; the disease is head and neck squamous cell carcinoma.