Subsequent studies have examined genome-wide methylation in larger samples of SLE patients using the HumanMethylation450 Beadchip (>485,000 CpG sites) in a number of cell types, including naïve CD4+ T cells [12,13,14,15,16], memory and regulatory T cells [17], CD19+ B cells [17], CD14+ monocytes [14,17], granulocytes [14], neutrophils [18], and whole blood or peripheral blood mononuclear cells (PBMC) [19,20,21,22,23,24,25]. Here, CD4 is linked to systemic lupus erythematosus.