During early puberty, the gonadotropin-releasing hormone system is essential for epididymo-testicular descent and for gonocytes transformation into fetal spermatogonia, so, in time, there were many attempts to identify a hormonal therapy in cryptorchidism, using choriogonadotropin (hCG), gonadotropin-releasing hormone (GnRH), or luteinizing hormone–releasing hormone (LHRH), either as a nasal spray or by intramuscular administration. The gene discussed is GNRH1; the disease is cryptorchidism.