SIRT7 and breast cancer: While SIRT7 has not been explicitly studied in the context of immunosenescence, Huo and coworkers reported that high levels of SIRT7 expression in breast cancer cells are correlated with poor prognosis, T cell exhaustion, and infiltration of pro-inflammatory M1-type macrophages [122], suggesting that SIRT7 activity may contribute to inflammaging and be detrimental to T cell homeostasis during aging.