Sirtuins contribute to T cell biology (Figure 6) and to the preservation of the health-span in the T cell compartment at multiple levels: SIRT1 has a complex role regulating TCR-mediated T cell responses, senescence, and helper T cell polarization; Sirt6 knockout in T cells produces systemic inflammation in mice, and high levels of SIRT7 expression in breast cancer are linked to T cell exhaustion. Here, SIRT7 is linked to breast carcinoma.