Moreover, some forms of OI associated with collagen type I deposition and mineralization are caused by mutations in SERPINF1 or IFITM5, while mutations in WNT1 or SP7 are linked to inhibition of chondrocyte differentiation and stimulation of osteoblast differentiation [36,37,38,39]. This evidence concerns the gene SERPINF1 and osteogenesis imperfecta.