NFKB1 and Alzheimer disease: Regarding AD and on a mechanistic point of view, andrographolide most likely conveys some anti-AD effects via its well-established antioxidant [45] and NFκB inhibitory and anti-inflammatory [46] properties as illustrated for instance by the fact that andrographolide inhibits Aβ1–42-induced production of neuroinflammatory mediators in microglia [13,14].