INS and breast carcinoma: [48] reported that cafitol inhibits breast cancer cell proliferation and induces cell death by inducing a caspase 3-dependent pathway [49] studied the effects of caffein on NB4, K562, HL60 and KG1 leukemia cell lines, and the results showed that caffein had the highest cytotoxicity to HL60 and KG1 cells, and could reduce the proliferation of HL60 cells by 100% [50] showed that caffein concentrations of 10−8 mol/L and 10−6 mol/L can increase insulin secretion by 12% and 16%, respectively, and long-term exposure can increase insulin secretion by 34% and 68%.