HSPG2 and astrocytoma (excluding glioblastoma): In fact, FPRL-1 is a receptor coupled to phospholipase C (PLC), able to mobilize intracellular calcium in U87 astrocytoma cells [20], by the activation of PLC/IP3 pathway [53] and the process of SOCE, which is implicated in the proliferation and tumor progression [54].