Fc-scTRAIL is a second-generation TRAIL-receptor agonist, produced by fusion of a single-chain TRAIL (scTRAIL) trimer to the Fc region of an IgG, resulting in an overall hexavalent TRAIL-receptor agonist that potently engages TRAIL receptor-mediated apoptosis in a wide range of cancer cells [12,13,14,15,16]. This evidence concerns the gene TNFSF10 and cancer.