In initial apoptosis studies, we demonstrated that the addition of ANG2 maintained the potency of hexavalent TRAIL in inducing apoptosis within the GBM cells, as determined by Annexin V-PI staining and efficient cleavage of the key apoptotic regulators, pro-caspase 8, pro-caspase 3 and PARP. Here, CASP3 is linked to glioblastoma.