Recently, inhibition of Akt-1 has been shown to induce metastasis through EGFR-mediated β-catenin nuclear accumulation in breast cancer cells, suggesting that the concomitant inhibition of Akt-1 and EGFR might be effective to limit the metastatic potential of Akt-1 inhibition [159]. The gene discussed is EGFR; the disease is breast carcinoma.