HM13 and cancer: For up-regulated DEGs, genes related to “response to virus” (GO:0009615), “type I interferon signaling pathway” (GO:0060337), “negative regulation of viral genome replication” (GO:0045071) were the top 3 up-regulated GO terms, indicating that the cell stress response and cytokine secretion of cancer cells were activated by SPP-0.7A.