NFKB1 and colorectal cancer: Most recently, fifteen NO2-FAs have been studied for their effects on activation of Nrf2, and inhibition of NF-κB signaling pathway, cyclooxygenase-2 (COX-2), LO and soluble Epoxide Hydrolase (sEH), as well as for their cytotoxic activity on colorectal cancer cells [34].