Characteristic lesions of PAH, like ventricular hypertrophy, fibrosis, etc., dropped significantly, unlike some biological markers like Monocyte Chemotactic Protein-1 (MCP-1), Interleukin-6 (IL-6), Tumor Necrosis Factor α (TNFα) and some macrophage markers (F4/80, CD68) levels in blood of High-Fat Diet (HFD) mice were increased. The gene discussed is CCL2; the disease is pulmonary arterial hypertension.