A study of human non-small-cell lung cancer cell line (A549) by Xie et al. [51] found that the alkaloid extract of M. oleifera significantly inhibited p-JAK2 and p-STAT3 and has dose-dependent effects, these results suggest that the M. oleifera leaf extract works by inhibiting the JAK2/STAT3 signaling pathway, it is closely related to the proliferation, angiogenesis, invasion, and migration of non-small-cell lung cancer, which induced the apoptosis and cell cycle block of A549 cells. Here, STAT3 is linked to non-small cell lung carcinoma.