Moreover, the 2D results also demonstrated that resveratrol could bind with IκB-alpha at Glu-49, Arg-50, and His-181 of the p65 to induce the apoptosis of U937 tumor cells [49], and the formation of H-bond interaction between the OH group of ferulic acid and TLR4 could combat against the LPS-induced neuroinflammation in the mouse brain [50]. The gene discussed is TLR4; the disease is neoplasm.