Both 6-FUmb and 8-FUmb, as well as parent Umb, exerted neuroprotective effects by inhibiting monoamine oxidase A (MAO-A), self-amyloid β aggregation, and lipid peroxidation, and could be considered as the multitarget-directed ligands for the treatment of depression [23]. Here, MAOA is linked to major depressive disorder.