The targeted molecules of SARS-CoV-2 for infection are as follows: spike (S), TMPRSS2, papain-like proteinase (PLpro), viral main protease (3C-like protease (3CLpro or Mpro)), non-structural protein 13 (Nsp13) helicase, open reading frame 7a (ORF7a), and RNA-dependent RNA polymerase (RdRp) (Nsp12), which are the proteins needed for making new virions because the host cells are killed by five different types of regulated cell death, viz., apoptosis, necroptosis, pyroptosis, autophagy, and PANoptosis. Here, TMPRSS2 is linked to infection.