F2RL1 and ichthyosis: The expression level of protease-activated receptor-2 (PAR-2), a key receptor regulating inflammation and ichthyosis in barrier-damaged skin [28,29], was higher in the LBE group (69,165 ± 1235/2 × 107 pixels) by approximately 8.7-fold compared to that in the control group (7084 ± 359/2 × 107 pixels).