The results of this study can be summarized as follows: (1) our surgeons were able to perform SND in patients with CEA abnormality in terms of thoracotomy, bilobectomy or pneumonectomy, cN1-2, pathological advanced stages, adjuvant chemotherapy ± radiotherapy, and EGFR or ALK; (2) SND was equivalent to L-SND in OS and DFS, and (c) There was no significant difference in local (p = 0.16), regional (p = 0.72), and distant (p = 0.39) tumor recurrence. The gene discussed is EGFR; the disease is neoplasm.