RUNX2 and osteoporosis: Patients with a heterozygous pathogenic frameshift variant, c.1205dupC, reflecting the role of RUNX2 protein in the maintenance of adult bone, presented with osteoporosis leading to recurrent bone fractures and scoliosis [84,85,86,87,88,89,90,91,92,93,94,95,96,97,98,99,100,101].