MOBP SNPs have been associated with Apolipoprotein-E e4 positive AD [14], FTD (and the severity of white matter degeneration [16,39]), PSP [17,40,41,42,43,44], Corticobasal Degeneration [43,44], while decreased expression of MOBP was revealed in familial Globular Glial Tauopathy [45] and differential DNA methylation of MOBP was shown in Multiple System Atrophy [46]. This evidence concerns the gene MOBP and supranuclear palsy, progressive, 1.