MOBP and supranuclear palsy, progressive, 1: Furthermore, there is a relationship between Single Nucleotide Polymorphisms (SNPs) in the MOBP genetic locus and frontotemporal dementia (FTD) [16], a disease strongly related to ALS [1], as well as progressive supranuclear palsy (PSP), an entity of the frontotemporal lobar degeneration (FTLD) spectrum pathology [17].